Anti-IL-6 Versus Anti-IL-6R Blocking Antibodies to Treat Acute Ebola Infection in BALB/c Mice: Potential Implications for Treating Cytokine Release Syndrome

October 7, 2021

Cytokine release syndrome (CRS) is known to be a factor in morbidity and mortality associated with acute viral infections including those caused by filoviruses and coronaviruses. IL-6 has been implicated as a cytokine negatively associated with survival after filovirus and coronavirus infection. However, IL-6 has also been shown to be an important mediator of innate […]

Geographic History of COVID-19 Variants

September 29, 2021

COVID-19 has constantly evolved since it first began to spread across the World in late 2019. Genomic sequencing efforts, as visualized in the map and chart, provided insight that the virus was not mutating rapidly with a common change. It wasn’t until late 2020, that variants of concern, Alpha, Beta, Gamma, and Delta started to […]

Flow Pharma Announces Publication of Pre-Clinical Efficacy Study for FlowVax COVID-19 Vaccine

May 20, 2021

The Peer Reviewed Journal Vaccines Has Published the Results of a Primate Study Showing Efficacy of the Flow Pharma’s COVID-19 Vaccine PLEASANT HILL, CA / ACCESSWIRE / May 19, 2021 / Flow Pharma, Inc., a San Francisco Bay Area biotechnology company developing the FlowVax™ peptide vaccine platform technology, today announced the publication of an article describing research performed […]

An Approach for a Synthetic CTL Vaccine Design Against Zika Flavivirus Using Class I and Class II Epitopes Identified by Computer Modeling

May 12, 2021

The threat posed by severe congenital abnormalities related to Zika virus (ZKV) infection during pregnancy has turned development of a ZKV vaccine into an emergency. Recent work suggests that the cytotoxic T lymphocyte (CTL) response to infection is an important defense mechanism in response to ZKV. Here, we develop the rationale and strategy for a […]

New Research: Paired SARS-CoV-2 spike protein mutations observed during ongoing SARS-CoV-2 viral transfer from humans to minks and Back to humans

PDF Publisher Website Abstract A mutation analysis of SARS-CoV-2 genomes collected around the world sorted by sequence, date, geographic location, and species has revealed a large number of variants from the initial reference sequence in Wuhan. This analysis also reveals that humans infected with SARS-CoV-2 have infected mink populations in the Netherlands, Denmark, United States, […]

Eliciting Cytotoxic T-lymphocyte Responses From Synthetic Vectors Containing One or Two Epitopes in a C57BL/6 Mouse Model Using Peptide-containing Biodegradable Microspheres and Adjuvants

May 7, 2021

1. IntroductionTo date, an effective vaccine for HIV has yet to be realized [1]. Here, we consider vaccines that fight the virus by inducing responses from cytotoxic T lymphocytes (CTLs). One key roadblock to an effective vaccine is that CTL-mediated attack of HIV infected cells is temporarily effective, but only until HIV mutates to escape […]